Lower Mississippi River Cruise with American Cruise Lines

04/04/2025 - 04/13/2025

Escorted by CTA Travel

Cruise through historical America

Cruising the Mississippi River and its tributaries with American Cruise Lines is an extraordinary journey through history. Embark on a unique riverboat adventure along the Lower Mississippi River between New Orleans, Louisiana and Memphis, Tennessee. Savor a week aboard our intimate and relaxed modern riverboat with 180 guests or fewer. Our enthusiastic all-American crew is ready to share with you a wonderful journey filled with historical tales, culinary delights, vibrant music, and new friends. Sail for 9-nights on the American Serenade.

from Call for pricing

Exclusive Group Departures